Source: | Rabbit | Gene Id: | 29128 |
Isotype: | IgG | Swiss Prot: | Q96T88 |
purity: | Affinity purification |
Background: |
UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin-protein ligase. It may participate in methylation-dependent transcriptional regulation. UHRF1 binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1's ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2. |
Reactivity | Human, |
Tested applications | WB IHC IF IP CHIP |
Clonality | Polyclonal Antibody |
Calculated MW | 91kDa |
Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20- 1:50
ChIP 1:20- 1:50
|
Immunogen | A recombinant protein of human UHRF1 |
Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | FLJ21925, ICBP90, MGC138707, Np95, RNF106, hNP95 |
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