| No | Size | Price | Availability | |
| ARP10411-01 | 50ul | 1500.00 | In Stock |  |
| ARP10411-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10411 |
| Isotype: | IgG | Swiss Prot: | O95398 |
| purity: | Affinity purification |
| Background: |
| EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 99kDa |
| Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50- 1:200
|
| Immunogen | A recombinant protein of human RAPGEF3 |
| Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | CAMP-GEFI, EPAC, EPAC1, HSU79275, MGC21410, bcm910 |
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