| No | Size | Price | Availability | |
| ARP3417-01 | 50ul | 1500.00 | In Stock |  |
| ARP3417-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3417 |
| Isotype: | IgG | Swiss Prot: | O75874 |
| purity: | Affinity purification |
| Background: |
| IDH1 is one of three isocitrate dehydrogenases that catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). These enzymes exist in two distinct subclasses that utilize either NAD or NADP+ respectively, as an electron acceptor (1). IDH1 is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. IDH2 and 3 are mitochodrial enzymes that also function in the Krebs cycle. IDH1 is inactivated by phosphorylation at Ser113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock (2,3). IDH1 is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma (4). IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway (5). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IP IF ChIP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 47 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
ChIP 1:20-1:100
Dot 1:20-1:100
|
| Immunogen | A recombinant protein of human IDH1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | IDCD, IDH, IDP, IDPC, PICD |
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