| No | Size | Price | Availability | |
| ARP3685-01 | 50ul | 1500.00 | In Stock |  |
| ARP3685-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3685 |
| Isotype: | IgG | Swiss Prot: | P06756 |
| purity: | Affinity purification |
| Background: |
| Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer (10-12). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 115 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide of human ITGAV |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CD51, MSK8, VNRA, VTNR |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
