FGR Rabbit Polyclonal Antibody
No Size Price Availability  
ARP2268-01 50ul 1500.00 In Stock
ARP2268-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 2268
Isotype: IgG Swiss Prot: P09769
purity: Affinity purification
Background:
Fgr is a member of the Src tyrosine kinase family. It has a membrane-associated amino-terminal domain that is highly divergent from other family members, internal conserved SH2 and SH3 domains and a highly conserved carboxy-terminal tyrosine kinase catalytic domain (1,2). Tyrosine 412 is located in the activation loop, and phosphorylation of this residue is critical for the activation of Fgr tyrosine kinase activity. c-Fgr is predominantly expressed in cells of hematopoietic origin including differentiated myeloid cells, NK and B cells (3,4). Fgr plays an important role in the signaling cascade from membrane receptors lacking intrinsic tyrosine kinase activity such as Bcr, FcR, and the integrin family of receptors (5). It was demonstrated that Fgr functions as a selective inhibitor of beta2 integrin-mediated signaling and Syk kinase function in monocytes (5).
Reactivity Human
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 56 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
Immunogen A synthetic peptide of human FGR
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym FGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr
This product is for research use only, not for diagnostic or therapeutic use!

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