| No | Size | Price | Availability | |
| ARP861-01 | 50ul | 1500.00 | In Stock |  |
| ARP861-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 861 |
| Isotype: | IgG | Swiss Prot: | Q01196 |
| purity: | Affinity purification |
| Background: |
| AML1 (also known as Runx1, CBFA2, and PEBP2αB) is a member of the core binding factor (CBF) family of transcription factors (1,2). It is required for normal development of all hematopoietic lineages (3-5). AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8;21) AML1-ETO, t(12;21) TEL-AML, and t(8;21) AML-M2 (6). Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner (7,8). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IP IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 51 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
ICC 1:50-1:200
|
| Immunogen | A synthetic peptide of human RUNX1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2Ab |
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