NT5E Rabbit Polyclonal Antibody
No Size Price Availability  
ARP4907-01 50ul 1500.00 In Stock
ARP4907-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 4907
Isotype: IgG Swiss Prot: P21589
purity: Affinity purification
Background:
Ecto-5'nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleoside (1). NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine-monophosphate, therefore driving the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors (2). Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promotor leads to upregulation of NT5E during hypoxia (3). NT5E biological roles span from lymphocyte adhesion (4,5), to fibrosis (6), to regulation of nociception (7,8).
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 63 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
Immunogen A recombinant protein of human NT5E
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym CD73, E5NT, NT, NT5, NTE, eN, Ent
This product is for research use only, not for diagnostic or therapeutic use!

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