| No | Size | Price | Availability | |
| ARP7321-01 | 50ul | 1500.00 | In Stock |  |
| ARP7321-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7321 |
| Isotype: | IgG | Swiss Prot: | P51668 |
| purity: | Affinity purification |
| Background: |
| The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. |
| Reactivity | Human, Mouse, Rat, |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 17kDa |
| Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
|
| Immunogen | A recombinant protein of human UBE2D1 |
| Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | SFT, UBCH5, UBC4/5, UBCH5A, E2(17)KB1 |
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