| No | Size | Price | Availability | |
| ARP10133-01 | 50ul | 1500.00 | In Stock |  |
| ARP10133-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10133 |
| Isotype: | IgG | Swiss Prot: | Q96CV9 |
| purity: | Affinity purification |
| Background: |
| This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 66kDa |
| Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
|
| Immunogen | A recombinant protein of human OPTN |
| Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP |
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