| No | Size | Price | Availability | |
| ARP966-01 | 50ul | 1500.00 | In Stock |  |
| ARP966-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 966 |
| Isotype: | IgG | Swiss Prot: | P13987 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Reactivity | Human, |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 19kDa |
| Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
|
| Immunogen | A recombinant protein of human CD59 |
| Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, _+E_MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20 |
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