| No | Size | Price | Availability | |
| ARP6426-01 | 50ul | 1500.00 | In Stock |  |
| ARP6426-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6426 |
| Isotype: | IgG | Swiss Prot: | Q07955 |
| purity: | Affinity purification |
| Background: |
| SF2/ASF is a member of the Ser-Arg-rich (SR) protein family of highly conserved nuclear phosphoproteins involved in pre-mRNA splicing (1). Besides its role in nuclear pre-mRNA splicing, SF2/ASF has been shown to shuttle between the nucleus and cytoplasm, suggesting additional roles in mRNA transport and cytoplasmic events (2). SF2/ASF associates with translating ribosomes and stimulates translation (3). It also activates translation initiation by suppressing the activity of 4E-BP1, which is mediated by SF2/ASF association with mTOR and the phosphatase PP2A (4). More recent studies have demonstrated a role for SF2/ASF in microRNA processing (5). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 28 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
|
| Immunogen | A recombinant protein of human SFRS1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ASF, MGC5228, SF2, SF2p33, SRp30a |
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