| No | Size | Price | Availability | |
| ARP3570-01 | 50ul | 1500.00 | In Stock |  |
| ARP3570-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3570 |
| Isotype: | IgG | Swiss Prot: | P08887 |
| purity: | Affinity purification |
| Background: |
| Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL6R, the complex of IL-6 and IL6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL6R has been found in human serum and urine. |
| Reactivity | Human, |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 52kD |
| Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
|
| Immunogen | A recombinant protein of human IL6R |
| Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | CD126,IL6R-1,IL6R-alpha,IL6RA,MGC104991 |
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