| No | Size | Price | Availability | |
| ARP10419-01 | 50ul | 1500.00 | In Stock |  |
| ARP10419-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10419 |
| Isotype: | IgG | Swiss Prot: | O14744 |
| purity: | Affinity purification |
| Background: |
| Human Skb1Hs methyltransferase (also called JBP1), a homologue of yeast protein Skb1 and Hsl7p (1,2), is composed of 637 amino acid residues and contains motifs conserved among protein methyltransferases. It methylates histones and MBP in vitro (2). Yeast Hsl7p is involved in regulation of cell cycle progression through G2 by negatively regulating Swe1p, a protein tyrosine kinase that phosphorylates and inhibits Cdc28p (3). An Hsl7p homologue, Skb1, was identified in fission yeast by virtue of its yeast two-hybrid interaction with Shk1p, a p21 (cdc42p/Rac) activated kinase (PAK) (4). Both proteins belong to the protein methyltransferase superfamily (5). Interestingly, human Skb1Hs methyltransferase was shown to interact with Jak kinases. This suggests the possibility that the Skb1Hs methyltransferase could link Jak to a PAK signaling pathway in mammalian cells. |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC IP IF ChIP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 73 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
ChIP 1:20-1:100
Dot 1:20-1:100
|
| Immunogen | A synthetic peptide of human PRMT5 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs, PRMT5, Skb1Hs Methyltransferase |
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