| No | Size | Price | Availability | |
| ARP4842-01 | 50ul | 1500.00 | In Stock |  |
| ARP4842-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4842 |
| Isotype: | IgG | Swiss Prot: | P29475 |
| purity: | Affinity purification |
| Background: |
| Nitric Oxide Synthase (NOS) catalyses the formation of nitric oxide (NO) and citruline from L-arginine, oxygen and cofactors. Three family members have been characterized: neuronal NOS (nNOS), which is found primarily in neuronal tissue; inducible NOS (iNOS), which is induced by interferon gamma and lipopolysaccharides in the kidney and cardiovascular system; and endothelial NOS (eNOS), which is expressed in blood vessels (1). NO is a messenger molecule with diverse functions throughout the body including the maintenance of vascular integrity, homeostasis, synaptic plasticity, long-term potentiation, learning, and memory (2,3). nNOS binds selectively to the second PDZ domain of PSD-95, and the enzymatic activity of nNOS is either downregulated by phosphorylation at Ser847 by CaM-KII or stimulated by calcium influxes governed by the NMDA receptor channels (4-5). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 160 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant Protein of human NOS1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | NOS1, IHPS1, N-NOS, NC-NOS, NOS, Bnos, nNOS |
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