| No | Size | Price | Availability | |
| ARP23385-01 | 50ul | 1500.00 | In Stock |  |
| ARP23385-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 23385 |
| Isotype: | IgG | Swiss Prot: | Q92542 |
| purity: | Affinity purification |
| Background: |
| Nicastrin is a transmembrane glycoprotein serving as an essential component of the γ-secretase complex (1,2). Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound γ-secretase complex (3). Nicastrin also serves as a docking site for γ-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to γ-secretase to ensure the correct cleavage process (2,4). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 77 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human NCSTN |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | NCSTN, APH2, KIAA0253 |
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