| No | Size | Price | Availability | |
| ARP6616-01 | 50ul | 1500.00 | In Stock |  |
| ARP6616-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6616 |
| Isotype: | IgG | Swiss Prot: | P60880 |
| purity: | Affinity purification |
| Background: |
| The 25 kDa synaptosome-associated protein (SNAP25) is a target membrane soluble, N-ethylmaleimide-sensitive factor attachment protein receptor (t-SNARE) that is found on neuronal presynaptic membranes. SNAP25 forms a core complex with the SNARE proteins syntaxin and synaptobrevin to mediate synaptic vesicle fusion with the plasma membrane during Ca2+-dependent exocytosis (1). This complex is responsible for exocytosis of the neurotransmitter γ-aminobutyric acid (GABA). Neurotransmitter release is inhibited by proteolysis of SNAP25 by botulinum toxins A and E (2). SNAP25 plays a secondary role as a Q-SNARE involved in endosome fusion; the protein is associated with genetic susceptibility to attention-deficit hyperactivity disorder (ADHD) (3). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IP IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 25 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:20-1:100
ICC 1:20-1:100
|
| Immunogen | A recombinant protein of human SNAP25 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | SNAP25, FLJ23079, RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2 |
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