| No | Size | Price | Availability | |
| ARP3611-01 | 50ul | 1500.00 | In Stock |  |
| ARP3611-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3611 |
| Isotype: | IgG | Swiss Prot: | Q13418 |
| purity: | Affinity purification |
| Background: |
| Integrin-linked kinases (ILKs) couple integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility (1). ILK functions as a scaffold bridging the extracellular matrix (ECM) and growth factor receptors to the actin cytoskeleton through interactions with integrin, PINCH (which links ILK to the RTKs via Nck2), CH-ILKBP and affixin (1). ILK phosphorylates Akt at Ser473, GSK-3 on Ser9, myosin light chain 2 (MLC2) on Ser18/Thr19, as well as affixin (2-5). These phosphorylation events are key regulatory steps in modulating the activities of the targets. ILK activity is stimulated by PI3 kinase and negatively regulated by the tumor suppressor PTEN and a PP2C protein phosphatase, ILKAP (1,3,6). It has been suggested that the conserved Ser343 residue in the activation loop plays a key role in the activation of ILK1 (2). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 59 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:100
|
| Immunogen | A recombinant protein of human ILK |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ILK, DKFZp686F1765, P59, ILK1 |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
