| No | Size | Price | Availability | |
| ARP1003-01 | 50ul | 1500.00 | In Stock |  |
| ARP1003-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1003 |
| Isotype: | IgG | Swiss Prot: | P33151 |
| purity: | Affinity purification |
| Background: |
| Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development (1). The classic cadherin subfamily includes N-, P-, R-, B- and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). While β- and γ-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking (1-4). E-cadherin is considered an active suppressor of invasion and growth of many epithelial cancers (1-3). Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion (3). In endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis (5,6). Expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers (7,8). |
| Reactivity | Human |
| Tested applications | WB FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 88 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
FC 1:20-1:50
|
| Immunogen | A synthetic peptide of human CDH5 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CDH5, Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, CD_antigen=CD144, Flags: Precursor |
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