| No | Size | Price | Availability | |
| ARP9314-01 | 50ul | 1500.00 | In Stock |  |
| ARP9314-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9314 |
| Isotype: | IgG | Swiss Prot: | O43474 |
| purity: | Affinity purification |
| Background: |
| KLF4 is a member of the erythroid Kruppel-like factor (EKLF) multigene family that is highly expressed in the differentiating layers of the epidermis (1, 2). KLF4 plays a critical role in the differentiation of epithelial cells and is essential for normal gastric homeostasis (2,3). Depending on the target gene, KLF4 can function as both a repressor and activator of transcription (4). Research studies suggest this protein may function as either a tumor suppressor or an oncogene depending on tumor type, with up-regulation in human squamous cell carcinoma of the head and neck and down-regulation in colorectal carcinoma (5,6). The in vitro reprogramming of somatic cells to an embryonic-like state has been achieved by retroviral transduction of four factors: Oct-3/4, Sox2, c-Myc, and KLF4 (7). These induced pluripotent stem cells (iPS) are of great therapeutic interest as they exhibit the key characteristics and growth properties of pluripotent stem cells (8,9). |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 51 kDa |
| Recommended Dilutions |
WB 1:50-1:100
IHC 1:10-1:50
|
| Immunogen | A synthetic peptide of human KLF4 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Kruppel-like factor 4, EZF, GKLF, KLF4 |
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