| No | Size | Price | Availability | |
| ARP5062-01 | 50ul | 1500.00 | In Stock |  |
| ARP5062-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5062 |
| Isotype: | IgG | Swiss Prot: | Q13177 |
| purity: | Affinity purification |
| Background: |
| PAK2, also named as PAK65, PAKgamma, p58, PAK-2p27, PAK-2p24 and C-t-PAK2, belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. PAK2 acts on a variety of targets. PAK2 catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein. PAK2 phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form. The antibody has no cross reaction to PAK1 and PAK3. |
| Reactivity | Human |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 58 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human PAK2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | PAK65, PAKgamma |
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