| No | Size | Price | Availability | |
| ARP578-01 | 50ul | 1500.00 | In Stock |  |
| ARP578-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 578 |
| Isotype: | IgG | Swiss Prot: | Q16611 |
| purity: | Affinity purification |
| Background: |
| Bak is a proapoptotic member of the Bcl-2 family (1). This protein is located on the outer membrane of mitochondria and is an essential component for transduction of apoptotic signals through the mitochondrial pathway (2,3). Upon apoptotic stimulation, an upstream stimulator like truncated BID (tBID) induces conformational changes in Bak to form oligomer channels in the mitochondrial membrane for cytochrome c release. The release of cytochrome c to the cytosol activates the caspase-9 pathway and eventually leads to cell death (4,5). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 23 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
ICC 1:50-1:200
|
| Immunogen | N term -peptide of human BAK1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, MGC117255, MGC3887 |
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