| No | Size | Price | Availability | |
| ARP22926-01 | 50ul | 1500.00 | In Stock |  |
| ARP22926-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 22926 |
| Isotype: | IgG | Swiss Prot: | P18850 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 75 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
|
| Immunogen | A C term -peptide of human ATF6 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ATF6, ATF6A, Processed cyclic AMP-dependent transcription factor ATF-6 alpha, Activating transcription factor 6 alpha |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
