| No | Size | Price | Availability | |
| ARP7014-01 | 50ul | 1500.00 | In Stock |  |
| ARP7014-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7014 |
| Isotype: | IgG | Swiss Prot: | Q15554 |
| purity: | Affinity purification |
| Background: |
| Telomeres, the linear ends of chromosomes, are organized into T-loops to prevent them from being recognized by the cell as DNA double stranded breaks (DSBs) (1). The telomeric repeat binding factor proteins Trf1 and Trf2 bind to double-stranded telomeres to allow formation of T-loops (2). A large number of proteins involved in the DNA damage response are found physically associated with Trf2 within telomeres (3). Interestingly, Trf2 can transiently localize to DNA damage-induced DSBs, but overexpression of Trf2 prevents ATM-dependent signaling (4). Phosphorylation of Trf2 at Ser323 has been reported in vivo, but no upstream kinase or role has been established for this phosphorylation site (5). |
| Reactivity | Human, Mouse |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 56 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A recombinant protein of human TERF2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | TRF2, TRBF2 |
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