| No | Size | Price | Availability | |
| ARP2891-01 | 50ul | 1500.00 | In Stock |  |
| ARP2891-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2891 |
| Isotype: | IgG | Swiss Prot: | P42262 |
| purity: | Affinity purification |
| Background: |
| AMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainate-, and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4), which assemble as homo- or hetero-tetramers to mediate the majority of fast excitatory transmissions in the central nervous system. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). In contrast to GluR 2-containing AMPARs, AMPARs that lack GluR 2 are permeable to calcium (2). Post-transcriptional modifications (alternative splicing, nuclear RNA editing) and post-translational modifications (glycosylation, phosphorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer’s, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 99 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A recombinant protein of human GRIA2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | GLUR2, GLURB, GluA2, HBGR2, GluR-K2 |
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