| No | Size | Price | Availability | |
| ARP6469-01 | 50ul | 1500.00 | In Stock |  |
| ARP6469-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6469 |
| Isotype: | IgG | Swiss Prot: | Q15465 |
| purity: | Affinity purification |
| Background: |
| Hedgehog proteins (Hh) are secreted signaling proteins that play many roles during animal development. Aberrant Hh signaling activity can be associated with numerous birth defects and uncontrolled Hh pathway activation is linked to the development of several types of cancers (1-2). The three identified vertebrate Hh genes are Sonic (Shh), Indian (Ihh) and Desert (Dhh), all of which have distinct as well as overlapping roles (3-5). Hh proteins are synthesized as 45 kDa precursors that undergo auto-cleavage to generate a 19 kDa amino-terminal peptide (Hh-N) and a carboxy-terminal peptide (Hh-C). The amino-terminal peptide becomes covalently attached to a cholesterol molecule at its carboxy terminus and acetylated at its amino terminus. This doubly modified Hh-N peptide is released from cells and responsible for all known Hedgehog signaling activity (6). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 50 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IF 1:20-1:50
|
| Immunogen | A synthetic peptide of human SHH |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS |
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