ARM999-24C [Monoclonal Antibody]
CDH1 Rabbit Monoclonal Antibody (Alexa Fluor(R) 647 Conjugate)
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Species:   Rabbit
Applications:   FC
Immunogen Range:   A synthetic peptide corresponding to the sequence surrounding Pro780 of human E-cadherin protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   999
Swiss Prot:   P12830
Synonyms:   Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Caculated MW:   135 kDa
Observed MW:   Refer to Figures
Applications:   FC 1:50
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information