ARMM016P-21
[Monoclonal Antibody]
Phospho-Ser CDKs Substrate Rabbit Monoclonal Antibody
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DATASHEET
Species: |
Rabbit |
Applications: |
WB IP |
Immunogen Range: |
A synthetic phospho-CDK substrate peptide library The antibody is formulated from two rabbit monoclones in order to cover a broad range of reactivity |
Clonality: |
Monoclonal Antibody |
Isotype: |
IgG |
GENE ID: |
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Swiss Prot: |
/ |
Synonyms: |
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Purification: |
Affinity purification |
Storage: |
Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Background: |
Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases that regulate cell-cycle transitions through their association and subsequent phosphorylation of targets in a strictly ordered fashion (1). The substrates for CDKs are proline-directed. The consensus amino acid sequence for CDK substrate is (K/R)(S*)PX(K/R), where X denotes any one of the 20 amino acids (2-4) and S* is the phosphorylation site. Phospho-(Ser) CDKs Substrate Antibody recognizes phosphorylated CDK substrates at their consensus motif, providing a powerful tool for CDK target discovery and characterization, as well as HTS drug screening for potential kinase regulators. |
Caculated MW: |
/ |
Observed MW: |
Refer to Figures |
Applications: |
WB 1:1000
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Reacitivity: |
Human |
For research use only. Not intended for diagnostic or therapeutic use!