ARM1499A-21 [Monoclonal Antibody]
Acetyl-CTNNB1-Lys49 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IP
Immunogen Range:   A synthetic acetylated peptide corresponding to residues surrounding Lys49 of human β-catenin protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   1499
Swiss Prot:   P35222
Synonyms:   CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, β-catenin
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   β-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM
Caculated MW:   92 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human, Monkey, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information