ARP7290-01
[Polyclonal Antibody]
HIRA Rabbit Polyclonal Antibody
www.yhsbio.com
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Species: |
Rabbit |
Applications: |
WB |
Immunogen Range: |
Recombinant protein of human HIRA |
Clonality: |
Polyclonal Antibody |
Isotype: |
IgG |
GENE ID: |
7290 |
Swiss Prot: |
P54198 |
Synonyms: |
TUP1, DGCR1, TUPLE1 |
Purification: |
Affinity purification |
Storage: |
Store at -20°C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background: |
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. |
Caculated MW: |
112kDa |
Observed MW: |
Refer to Figures |
Applications: |
WB 1:500-1:2000
|
Reacitivity: |
Human |
For research use only. Not intended for diagnostic or therapeutic use!