ARP4088P-21
[Polyclonal Antibody]
Phospho-SMAD3-Ser423/425 Rabbit Polyclonal Antibody
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Species: |
Rabbit |
Applications: |
WB IP IF FC |
Immunogen Range: |
/ |
Clonality: |
Polyclonal Antibody |
Isotype: |
/ |
GENE ID: |
4088 |
Swiss Prot: |
P84022 |
Synonyms: |
HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 |
Purification: |
Affinity purification |
Storage: |
Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Background: |
Smad proteins belong to a group of intracellular signal transducers and downstream effectors of TGF-β/BMP Signaling. The family consists of nine members that are highly conserved in the N- and C-terminal regions. Smad3 is a key component in intracellular signaling of transforming growth factor beta (TGF-β), an inhibitor for tumor cell proliferation. Smad3 is activated by activin/TGF-β receptors, which form a heteromeric complex with Smad4, translocating to the nucleus and regulating the expression of TGF- β target genes. Interaction of Smad3 with Akt, can initiate TGF- β induced apoptosis and cell cycle arrest. Smad3 expression may be critical in tumor suppression in early stages of gastric carcinogenesis. |
Caculated MW: |
52 kDa |
Observed MW: |
Refer to Figures |
Applications: |
|
Reacitivity: |
/ |
For research use only. Not intended for diagnostic or therapeutic use!