
| Species: | Rabbit |
| Applications: | WB IHC IF |
| Immunogen Range: | KLH conjugated synthetic peptide derived from human RNF156 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 23295 |
| Swiss Prot: | |
| Synonyms: | E3 ubiquitin-protein ligase MGRN1, KIAA0544, Mahogunin ring finger 1, Mahogunin RING finger protein 1, MGRN 1, MGRN1, MGRN1_HUMAN, Probable E3 ubiquitin protein ligase MGRN1, RING finger protein 156, RNF 156. |
| Purification: | Purified by Protein A. |
| Storage: | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Background: | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. |
| Caculated MW: | / |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:100-1:1000 IHC 1:100-1:500 IF 1:50-1:200 |
| Reacitivity: | Human, Mouse, Rat |