YRP10208-01 [Polyclonal Antibody]
HPV31 E7 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from HPV31 E7 protein
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:  
Swiss Prot:  
Synonyms:   VE7_HPV31, Protein E7, E7, Human Papilloma Virus, Human papillomavirus type 31 E7, Human papillomavirus type 31 E7, Human papillomavirus type 31 E7, Human papillomavirus type 31 E7 protein, Protein E7, HPV31 E7 protein.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Virus (HPV31)
For research use only. Not intended for diagnostic or therapeutic use!
Additional information