Species: | Rabbit |
Applications: | WB IHC IF |
Immunogen Range: | KLH conjugated synthetic peptide derived from human ALK1 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 94 |
Swiss Prot: | P37023 |
Synonyms: | HHT, ALK1, HHT2, ORW2, SKR3, ALK-1, TSR-I, ACVRLK1, Serine/threonine-protein kinase receptor R3, Activin receptor-like kinase 1, TGF-B superfamily receptor type I, ACVRL1 |
Purification: | Purified by Protein A. |
Storage: | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
Background: | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
Caculated MW: | / |
Observed MW: | Refer to Figures |
Applications: |
WB 1:100-1:1000 IHC 1:100-1:500 IF 1:50-1:200 |
Reacitivity: | Human, Mouse, Rat |