Species: | Rabbit |
Applications: | FC IHC IF |
Immunogen Range: | KLH conjugated synthetic peptide derived from rat CD45 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 24699 |
Swiss Prot: | P04157 |
Synonyms: | Lca, RT7, CD45, L-CA, T200, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, Ptprc |
Purification: | Purified by Protein A. |
Storage: | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
Background: | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). |
Caculated MW: | / |
Observed MW: | Refer to Figures |
Applications: |
IHC 1:100-1:500 IF 1:50-1:200 FC 1:20-1:100 |
Reacitivity: | Rat |