YRP03464P-01 [Polyclonal Antibody]
Phospho-Tuberin (Ser1254) Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC IF
Immunogen Range:   KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1254 [SL(p-S)VP]
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   7249
Swiss Prot:  
Synonyms:   Tuberin Ser1254, TSC2 Ser1254, P-Tuberin/TSC2 Ser1254, P-TSC2 Ser1254FLJ43106, LAM, TSC2, TSC2_HUMAN, TSC4, Tuberin, Tuberous sclerosis 2 protein.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information