YRP00684-01 [Polyclonal Antibody]
SYVN1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IHC-F IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human SYVN1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   84447
Swiss Prot:   Q86TM6
Synonyms:   DER3, HRD1, E3 ubiquitin-protein ligase synoviolin, Synovial apoptosis inhibitor 1, SYVN1, KIAA181
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information