YRP18149-01 [Polyclonal Antibody]
IL1RAP Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   3556
Swiss Prot:   Q9NPH3
Synonyms:   IL1R3, C3orf13, IL-1RAcP, Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information