YRP13260-01 [Polyclonal Antibody]
GAB3 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human GAB3
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   139716
Swiss Prot:  
Synonyms:   Gab3, GAB3_HUMAN, GRB2-associated binder 3, GRB2-associated-binding protein 3, Growth factor receptor bound protein 2-associated protein 3.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1–3). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (1–3). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information