YRP12399-01 [Polyclonal Antibody]
DTX2 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human DTX2
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   113878
Swiss Prot:  
Synonyms:   Deltex 2, Deltex2, hDTX2, Highly similar to hPMSR6 [H.sapiens], Protein deltex 2, RING finger protein 58, RNF58, Zinc ion binding protein, DTX2_HUMAN.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information