YRP12333-01 [Polyclonal Antibody]
TCR alpha Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB FC IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human TCR alpha
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   171558
Swiss Prot:  
Synonyms:   T cell antigen receptor alpha polypeptide, T cell receptor alpha, T cell receptor alpha locus, TCRA, TCRD, TRA, PTCRA_HUMAN.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Maturation of cytotoxic T lymphocytes is mediated in part by a structure on the T cell surface known as the T cell antigen receptor (TCR) complex. The pre-TCR complex consists of pre-TCR ?¡À, pre-TCR ?2and CD3, which together help coordinate early thymocyte development. Pre-TCR ?¡À chain is a type I transmembrane glycoprotein with an extracellular region similar to the constant domain of the immunoglobulin supergene family. Notch3 transgenic mice lacking pre-TCR ?¡À inhibits tumor development. In humans, acute lymphoblastic leukemias (ALL) in remission have lower transcript levels of Notch3, HES-1 and pre-TCR ?¡À transcripts a and b relative to proliferating ALLs. The human pre-TCR ?¡À gene is expressed in immature T cells and maps to chromosome 6p
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
FC 1:20-1:100
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information