ARP6786-01 [Polyclonal Antibody]
STIM1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF IP FC
Immunogen Range:   Recombinant protein of human STIM1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   6786
Swiss Prot:   Q13586
Synonyms:   GOK, TAM, TAM1, IMD10, STRMK, D11S4896E
Purification:   Affinity purification
Storage:   Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background:   This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Caculated MW:   77kDa
Observed MW:   Refer to Figures
Applications:   WB 1:200-1:2000
IHC 1:20-1:200
IF 1:10-1:100
FC 1:20-1:50
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information