Species: | Rabbit |
Applications: | WB IHC IF |
Immunogen Range: | Recombinant protein of human POLK |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 51426 |
Swiss Prot: | Q9UBT6 |
Synonyms: | DINP, POLQ, DINB1 |
Purification: | Affinity purification |
Storage: | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background: | External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 |
Caculated MW: | 98 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200 |
Reacitivity: | Human, Mouse, Rat |