ARP4092-01 [Polyclonal Antibody]
SMAD7 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   Recombinant protein of human SMAD7
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   4092
Swiss Prot:   O15105
Synonyms:  
Purification:   Affinity purification
Storage:   Store at 4°C (regular) or -20°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background:   The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Caculated MW:   46 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
IHC 1:50-1:100
IF 1:20-1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information