Species: | Rabbit |
Applications: | WB IHC IF IP ChIP |
Immunogen Range: | Recombinant protein of human SETD2 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 29072 |
Swiss Prot: | Q9BYW2 |
Synonyms: | HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBP |
Purification: | Affinity purification |
Storage: | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background: | Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. |
Caculated MW: | 287 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200 |
Reacitivity: | Human, Mouse, Rat |