ARP1991-51 [Polyclonal Antibody]
ELANE Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA IP IF
Immunogen Range:   A synthetic peptide corresponding to amino acids 211-267 mapping at the C-terminus of human ELANE
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   1991
Swiss Prot:   P08246
Synonyms:   GE, NE, HLE, HNE, ELA2, SCN1, PMN-E
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Caculated MW:   29 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IF 1:50-1:500
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information