ARP2670-31 [Polyclonal Antibody]
GFAP Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ICC
Immunogen Range:   A recombinant protein of human GFAP
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   2670
Swiss Prot:   P14136
Synonyms:   GFAP,FLJ45472
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The cytoskeleton consists of three types of cytosolic fibers: microfilaments (actin filaments), intermediate filaments, and microtubules. Major types of intermediate filaments are specifically expressed in particular cell types: cytokeratins in epithelial cells, glial fibrillary acidic protein (GFAP) in glial cells, desmin in skeletal, visceral, and certain vascular smooth muscle cells, vimentin in cells of mesenchymal origin, and neurofilaments in neurons. GFAP and vimentin form intermediate filaments in astroglial cells and modulate their motility and shape. In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspinal tumors arising from astrocytes. In addition, GFAP intermediate filaments are also present in non-myelin-forming Schwann cells in the peripheral nervous system.
Caculated MW:   50 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:400
IHC 1:50-1:200
ICC 1:100-1:500
Reacitivity:   Dog, Human, Mouse, Pig, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information