ARP3551-31 [Polyclonal Antibody]
IKBKB Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC ICC
Immunogen Range:   A synthetic peptide of human IKBKB
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   3551
Swiss Prot:   O14920
Synonyms:   FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation (10-13).
Caculated MW:   81 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50-1:200
ICC 1:100-1:500
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information