ARP2534-31 [Polyclonal Antibody]
FYB Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ELISA IF ICC
Immunogen Range:   A synthetic peptide derived from human FYB/ADAP
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   2533
Swiss Prot:   O15117
Synonyms:   ADAP, PRO0823, SLAP130, SLAP-130
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Fyb (Fyn binding protein) and the anchoring proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells (1–3). SKAP55 contains an amino-terminal pleckstrin homology domain and a carboxy-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human Fyb gene maps to chromosome 5p13.1 and encodes a 783 amino acid protein.
Caculated MW:   85 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:500
IHC 1:100-1:500
IF 1:100-1:500
ICC 1:100-1:500
Reacitivity:   Chicken, Cow, Dog, Horse, Human, Mouse, Pig, Rat, Sheep
For research use only. Not intended for diagnostic or therapeutic use!
Additional information