RMM177105-21 [Monoclonal Antibody]
IL1RN Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB IF
Immunogen Range:   A fusion protein corresponding to the amino terminus of rat IRAP
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   171105(Rat)
Swiss Prot:   P97629
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   IRAP (also known as LNPEP) was originally described as an insulin-responsive aminopeptidase found in Glut4-containing vesicles (1). It is essentially always in the same compartments as Glut4 and has identical insulin-stimulated translocation patterns as Glut4 (2). IRAP is therefore considered to be a surrogate marker for Glut4 (2). IRAP was later found to be a critical enzyme that regulates the expression and activity of several essential hormones and regulatory proteins, including the Glut4 transporter (3,4). This membrane associated, zinc-dependent cystinyl aminopeptidase acts as both a receptor for angiotensin IV as well as the enzyme that catalyzes the synthesis of this essential hormone from its angiotensinogen precursor (5). IRAP catalyzes the hydrolysis of several peptide hormones, including oxytocin and vasopressin (4). Abnormal IRAP expression or activity is associated with several forms of cancer in humans, including renal and endometrial cancers (6,7).
Caculated MW:   165 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:1600
Reacitivity:   Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information