ARM836C-23C [Monoclonal Antibody]
Cleaved CASP3 (Asp175) Rabbit Monoclonal Antibody (Alexa Fluor(R) 488 Conjugate)
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Species:   Rabbit
Applications:   IF FC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Asp175 of human caspase-3 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   836
Swiss Prot:   P42574
Synonyms:   CPP32, CPP32B, SCA-1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
Caculated MW:   17, 19 kDa
Observed MW:   Refer to Figures
Applications:   IF 1:50
FC 1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information